منابع مشابه
Mitotic chromosome scaffold structure: new approaches to an old controversy.
I this modern era of genome sequencing and structural genomics, the fundamental question of how chromatin folds into mitotic chromosomes remains a mystery. In higher eukaryotic cells, mitotic chromosome condensation leads to an 10,000to 20,000fold compaction, as defined by the ratio of the DNA length to metaphase chromosome length (1). Compaction is achieved through at least three levels of chr...
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Cells have evolved certain precautions to preserve their genomic content during mitosis and avoid potentially oncogenic errors. Besides the well-established DNA damage checkpoint and spindle assembly checkpoint (SAC), recent observations have identified an additional mitotic failsafe referred to as the mitotic surveillance pathway. This pathway triggers a cell cycle arrest to block the growth o...
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In this paper, the concept of fuzzy automata normed linear structure spaces is introduced and suitable examples are provided. ;The ;concepts of fuzzy automata $alpha$-open sphere, fuzzy automata $mathscr{N}$-locally compact spaces, fuzzy automata $mathscr{N}$-Hausdorff spaces are also discussed. Some properties related with to fuzzy automata normed linear structure spaces and fuzzy automata $ma...
متن کاملThe Mitotic Chromosome: Structure and Mechanics
Cell division requires replication of DNA followed by physical segregation of chromosomes and replicated chromatids. DNA replication is likely to leave duplicate sister chromatids wrapped around one another (catenated) at least once every few kilobases (Chapter 15). Then, as the cell enters mitosis, chromosomes are folded (“condensed”) into neatly compacted and segregated mitotic chromosomes ea...
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From observations on the partial disintegration of isolated human metaphase chromosomes we propose that human metaphase chromatids have a rather simple organization based on the folding and coiling of a long, regular, hollow cylindrical structure with a diameter of about 4000 A. This cylindrical structure, the unit fiber, is postulated to be a super-solenoid formed by the coiling of a 300 A sol...
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ژورنال
عنوان ژورنال: Science
سال: 1915
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.42.1090.727